齋藤潤　研究室

​2023

• Wang J, Saiki N, Tanimura A, Noma T, Niwa A, Nakahata T, Saito MK*. UK-5099, a mitochondrial pyruvate carrier inhibitor, recovers impaired neutrophil maturation caused by AK2 deficiency in human pluripotent stem cell models. Biochem Biophys Res Commun. 2023 Nov 3;687:149211. doi: 10.1016/j.bbrc.2023.149211. 

• Kitagawa Y, Ikenaka A, Sugimura R, Niwa A, Saito MK*. ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation. iScience. 2023 Sep 9;26(10):107893. doi: 10.1016/j.isci.2023.107893. eCollection 2023 Oct 20. 10.1016/j.isci.2023.107893

• Hosokawa M, Mikawa R, Hagiwara A, Okuno Y, Awaya T, Yamamoto Y, Takahashi S, Yamaki H, Osawa M, Setoguchi Y, Saito MK, Abe S, Hirai T, Gotoh S, Hagiwara M. Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC. iScience. 2023 Aug 25;26(10):107731. doi: 10.1016/j.isci.2023.107731. eCollection 2023 Oct 20. 10.1016/j.isci.2023.107731

• Saito MK*, Osawa M, Tsuchida N, Shiraishi K, Niwa A, Woltjen K, Asaka I, Ogata K, Ito S, Kobayashi S, Yamanaka S. A disease-specific iPS cell resource for studying rare and intractable diseases. Inflamm Regen. 2023 Sep 8;43(1):43. doi: 10.1186/s41232-023-00294-2.10.1186/s41232-023-00294-2

• Ueki Y, Takimoto-Ito R, Saito MK, Tanizaki H, Kambe N. Tofacitinib, a suppressor of NOD2 expression, is a potential treatment for Blau syndrome. Front Immunol. 2023 Jun 21;14:1211240. doi: 10.3389/fimmu.2023.1211240. eCollection 2023.10.3389/fimmu.2023.1211240

• Kase N, Kitagawa Y, Ikenaka A, Niwa A, Saito MK*. A concise in vitro model for evaluating interactions between macrophage and skeletal muscle cells during muscle regeneration. Front Cell Dev Biol. 2023 May 18;11:1022081. doi: 10.3389/fcell.2023.1022081. eCollection 2023.10.3389/fcell.2023.1022081

• Hayashi T, Yano N, Kora K, Yokoyama A, Maizuru K, Kayaki T, Nishikawa K, Osawa M, Niwa A, Takenouchi T, Hijikata A, Shirai T, Suzuki H, Kosaki K, Saito MK, Takita J, Yoshida T. Involvement of mTOR pathway in neurodegeneration in NSF-related developmental and epileptic encephalopathy. Hum Mol Genet. 2023 May 5;32(10):1683-1697. doi: 10.1093/hmg/ddad008.10.1093/hmg/ddad008

• Ikenaka A, Kitagawa Y, Yoshida M, Lin CY, Niwa A, Nakahata T, Saito MK*. SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis. Life Sci Alliance. 2023 Jan 5;6(3):e202201457. doi: 10.26508/lsa.202201457. Print 2023 Mar.10. 26508/lsa.202201457

 

2022

• Oh S, Niwa A, Nagahashi A, Asaka I, Nakahata T, Saito MK*. iPS cells from Chediak-Higashi syndrome patients recapitulate the giant granules in myeloid cells. Pediatr Int. 2022 Oct 19:e15390. doi: 10.1111/ped.15390. Online ahead of print.

• Linder MI, Mizoguchi Y, Hesse S, Csaba G, Tatematsu M, Łyszkiewicz M, Zietara N, Jeske T, Hastreiter M, Rohlfs M, Liu Y, Grabowski P, Ahomaa K, Maier-Begandt D, Schwestka M, Pazhakh V, Isiaku A, Briones Miranda B, Blombery P, Saito MK, Rusha E, Alizadeh Z, Pourpak Z, Kobayashi M, Rezaei N, Unal E, Hauck F, Drukker M, Walzog B, Rappsilber J, Zimmer R, Lieschke GJ, Klein C. Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes. Blood. 2022 Oct 11:blood.2022016783. doi: 10.1182/blood.2022016783. Online ahead of print.

• Miyamoto T, Honda Y, Izawa K, Kanazawa N, Kadowaki S, Ohnishi H, Fujimoto M, Kambe N, Kase N, Shiba T, Nakagishi Y, Akizuki S, Murakami K, Bamba M, Nishida Y, Inui A, Fujisawa T, Nishida D, Iwata N, Otsubo Y, Ishimori S, Nishikori M, Tanizawa K, Nakamura T, Ueda T, Ohwada Y, Tsuyusaki Y, Shimizu M, Ebato T, Iwao K, Kubo A, Kawai T, Matsubayashi T, Miyazaki T, Kanayama T, Nishitani-Isa M, Nihira H, Abe J, Tanaka T, Hiejima E, Okada S, Ohara O, Saito MK, Takita J, Nishikomori R, Yasumi T. Assessment of type I interferon signatures in undifferentiated inflammatory diseases: A Japanese multicenter experience. Front Immunol. 2022 Sep 23;13:905960. doi: 10.3389/fimmu.2022.905960. eCollection 2022.

• Maekawa H, Jin Y, Nishio M, Kawai S, Nagata S, Kamakura T, Yoshitomi H, Niwa A, Saito MK, Matsuda S, Toguchida J.Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs. Orphanet J Rare Dis. 2022 Sep 21;17(1):364. doi: 10.1186/s13023-022-02506-3.

• Yamane J, Wada T, Otsuki H, Inomata K, Suzuki M, Hisaki T, Sekine S, Kouzuki H, Kobayashi K, Sone H, Yamashita JK, Osawa M, Saito MK, Fujibuchi W. StemPanTox: A fast and wide-target drug assessment system for tailor-made safety evaluations using personalized iPS cells iScience. 2022 Jun 6;25(7):104538. doi: 10.1016/j.isci.2022.104538. eCollection 2022 Jul 15.

• Matsuda T, Kambe N, Takimoto-Ito R, Ueki Y, Nakamizo S, Saito MK, Takei S and Kanazawa N. Potential Benefits of TNF Targeting Therapy in Blau Syndrome, a NOD2-Associated Systemic Autoinflammatory Granulomatosis. Front. Immunol. 13:895765. doi: 10.3389/fimmu.2022.895765

• Tanaka T, Shiba T, Honda Y, Izawa K, Yasumi T, Saito MK, Nishikomori R. Induced Pluripotent Stem Cell-Derived Monocytes/Macrophages in Autoinflammatory Diseases. Front. Immunol. 2022 online ahead of print. doi: 10.3389/fimmu.2022.870535

• Nishitani-Isa M, Mukai K, Honda Y, Nihira H, Tanaka T, Shibata H, Kodama K, Hiejima E, Izawa K, Kawasaki Y, Osawa M, Katata Y, Onodera S, Watanabe T, Uchida T, Kure S, Takita J, Ohara O, Saito MK, Nishikomori R, Taguchi T, Sasahara Y, Yasumi T. Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation. J Exp Med. 2022 Jun 6;219(6):e20211889.

• Song D, Takahashi G, Zheng YW, Matsuo-Takasaki M, Li J, Takami M, An Y, Hemmi Y, Miharada N, Fujioka T, Noguchi M, Nakajima T, Saito MK, Nakamura Y, Oda T, Miyaoka Y, Hayashi Y. Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson's disease-specific hepatocytes. Hum Mol Genet. 2022 Apr 7. Online ahead of print.

• Shimizu T, Matsuo-Takasaki M, Luijkx D, Takami M, Arai Y, Noguchi M, Nakamura Y, Hayata T, Saito MK, Hayashi Y. Generation of human induced pluripotent stem cell lines derived from four DiGeorge syndrome patients with 22q11.2 deletion. Stem Cell Res. 2022 Mar 9;61:102744. 

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2021

• Fukui Y, Hayano S, Kawanabe N, Wang Z, Shimada A, Saito MK, Asaka I, Kamioka H. Investigation of the molecular causes underlying physical abnormalities in Diamond-Blackfan anemia patients with RPL5 haploinsufficiency. Pathol Int. 2021 Sep 29. doi: 10.1111/pin.13168. Online ahead of print.

• Toshikawa H, Ikenaka A, Li L, Nishinaka-Arai Y, Niwa A, Ashida A, Kazuki Y, Nakahata T, Tamai H, Russell DW, Saito MK*. N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21. Sci Rep. 2021 Aug 30;11(1):17377. doi: 10.1038/s41598-021-96697-7.　解説

• Kitagawa Y, Kawasaki Y, Yamasaki Y, Kambe N, Takei S, Saito MK*. Anti-TNF treatment corrects IFN-γ-dependent proinflammatory signatures in Blau syndrome patient-derived macrophages. J Allergy Clin Immunol. 2021 Jun 24:S0091-6749(21)00888-5. doi: 10.1016/j.jaci.2021.05.030. Online ahead of print.　解説

• Kuramochi Y, Awaya T, Matsuo-Takasaki M, Takami M, An Y, Li J, Hemmi Y, Wakabayashi T, Arai Y, Inoue J, Noguchi M, Nakamura Y, Asaka I, Akimoto K, Saito MK*, Hayashi Y. Generation of two human induced pluripotent stem cell lines derived from two X-linked adrenoleukodystrophy patients with ABCD1 mutations. Stem Cell Res. 2021 May;53:102337. doi: 10.1016/j.scr.2021.102337. Epub 2021 Apr 15.

• Matsuo S, Nishinaka-Arai Y, Kazuki Y, Oshimura M, Nakahata T, Niwa A, Saito MK*. Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification. PLoS One. 2021 Mar 29;16(3):e0247595. doi: 10.1371/journal.pone.0247595. eCollection 2021.

• Mu A, Hira A, Niwa A, Osawa M, Yoshida K, Mori M, Okamoto Y, Inoue K, Kondo K, Kanemaki MT, Matsuda T, Ito E, Kojima S, Nakahata T, Ogawa S, Tanaka K, Matsuo K, Saito MK, Takata M. Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency. Blood. 2021 Apr 15;137(15):2021-2032. doi: 10.1182/blood.2020009111.

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2020

• Lin CY, Yoshida M, Li LT, Saito MK*. In vitro Neuromuscular Junction Induced from Human Induced Pluripotent Stem Cells. J Vis Exp. 2020 Dec 3;(166). doi: 10.3791/61396.

• Kase N, Terashima M, Ohta A, Niwa A, Honda-Ozaki F, Kawasaki Y, Nakahata T, Kanazawa N, Saito MK*. Pluripotent stem cell-based screening identifies CUDC-907 as an effective compound for restoring the in vitro phenotype of Nakajo-Nishimura syndrome. Stem Cells Transl Med. 2021 Mar;10(3):455-464. doi: 10.1002/sctm.20-0198. Epub 2020 Oct 14.　解説

• Yamamoto-Shimojima K, Osawa M, Saito MK, Yamamoto T. Induced pluripotent stem cells established from a female patient with Xq22 deletion confirm that BEX2 escapes from X-chromosome inactivation. Congenit Anom (Kyoto). 2021 Mar;61(2):63-67. doi: 10.1111/cga.12403. Epub 2020 Dec 13.

• Hamabata T, Umeda K, Kouzuki K, Tanaka T, Daifu T, Nodomi S, Saida S, Kato I, Baba S, Hiramatsu H, Osawa M, Niwa A, Saito MK, Kamikubo Y, Adachi S, Hashii Y, Shimada A, Watanabe H, Osafune K, Okita K, Nakahata T, Watanabe K, Takita J, Heike T. Pluripotent stem cell model of Shwachman-Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors. Sci Rep. 2020 Sep 9;10(1):14859. doi: 10.1038/s41598-020-71844-8.

• Seki R, Ohta A, Niwa A, Sugimine Y, Naito H, Nakahata T, Saito MK*. Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity. PLoS One. 2020 Aug 18;15(8):e0237030. doi: 10.1371/journal.pone.0237030. eCollection 2020.

• Matsuda T, Kambe N, Ueki Y, Kanazawa N, Izawa K, Honda Y, Kawakami A, Takei S, Tonomura K, Inoue M, Kobayashi H, Okafuji I, Sakurai Y, Kato N, Maruyama Y, Inoue Y, Otsubo Y, Makino T, Okada S, Kobayashi I, Yashiro M, Ito S, Fujii H, Kondo Y, Okamoto N, Ito S, Iwata N, Kaneko U, Doi M, Hosokawa J, Ohara O, Saito MK, Nishikomori R; PIDJ members in the JSIAD; PIDJ (Primary Immunodeficiency and Autoinflammatory Diseases Database Project) members in the JSIAD (Japanese Society for Immunodeficiency and Autoinflammatory Diseases). Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation. Ann Rheum Dis. 2020 Jul 9 2020;79:1492-1499: annrheumdis-2020-217320. doi: 10.1136/annrheumdis-2020-217320.

• Nishinaka-Arai Y, Niwa A, Matsuo S, Kazuki Y, Yakura Y, Hiroma T, Toki T, Sakuma T, Yamamoto T, Ito E, Oshimura M, Nakahata T, Saito MK*. Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation. Haematologica. 2020 Apr 30:haematol.2019.242693. doi: 10.3324/haematol.2019.242693.　解説

• Takada S, Saito MK, Kambe N. Blau syndrome: NOD2-related systemic autoinflammatory granulomatosis. G Ital Dermatol Venereol. 2020 Jul 2. doi: 10.23736/S0392-0488.19.06524-6. 

• Sugimura R, Ohta R, Mori C, Li A, Mano T, Sano E, Kosugi K, Nakahata T, Niwa A, Saito MK*, Torisawa Y. Biomimetic Aorta-Gonad-Mesonephros-on-a-Chip to Study Human Developmental Hematopoiesis. Biomedical Microdevices. 2020 May 6;22(2):34. doi: 10.1007/s10544-020-00488-2.

• Matsuda M, Yamanaka Y, Uemura M, Osawa M, Saito MK, Nagahashi A, Nishio M, Guo L, Ikegawa S, Sakurai S, Kihara S, Maurissen TL, Nakamura M, Matsumoto T, Yoshitomi H, Ikeya M, Kawakami N, Yamamoto T, Woltjen K, Ebisuya M, Toguchida J, Alev C. Recapitulating the Human Segmentation Clock with Pluripotent Stem Cells. Nature. 580, 124–129 (2020). https://doi.org/10.1038/s41586-020-2144-9.　解説

 

​2019

• Grajcarek J, Monlong J, Nishinaka-Arai Y, Nakamura M, Nagai M, Matsuo S, Lougheed D, Sakurai H, Saito MK, Bourque G, Woltjen K. Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations. Nature Commuications. 2019 Oct 24;10(1):4856. doi: 10.1038/s41467-019-12829-8.

• Shiba T, Tanaka T, Ida H, Watanabe M, Nakaseko H, Osawa M, Shibata H, Izawa K, Yasumi T, Kawasaki Y, Saito MK, Takita J, Heike T, Nishikomori R. Functional　evaluation of the pathological significance of MEFV variants using induced　pluripotent stem cell-derived macrophages. J Allergy Clin Immunol. 2019 Sep 13.　pii: S0091-6749(19)31039-5. doi: 10.1016/j.jaci.2019.07.039. [Epub ahead of print] PPMID: 31542286.

• Lin CY, Yoshida M, Li LT, Ikenaka A, Oshima S, Nakagawa K, Sakurai H, Matsui E, Nakahata T, Saito MK*. iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases. JCI Insight. 2019 Sep 19;4(18). pii: 124299. doi: 10.1172/jci.insight.124299. PubMed PMID: 31534050. 　解説

• Ohta R, Sugimura R, Niwa A, Saito MK*. Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition. J Vis Exp. 2019 Jun 16;(148). doi: 10.3791/59823. PMID: 31259914

• Kanazawa N, Honda-Ozaki F, Saito MK. Induced pluripotent stem cells representing Nakajo-Nishimura syndrome. Inflamm Regen. 2019 May 23;39:11. doi: 10.1186/s41232-019-0099-8. eCollection 2019. Review.

• Kunimoto K, Honda-Ozaki F, Saito MK, Furukawa F, Kanazawa N. Beneficial effect of methotrexate on a child case of Nakajo-Nishimura syndrome. J Dermatol. 2019 May 6. doi: 10.1111/1346-8138.14907. [Epub ahead of print].

• Matsubara H, Niwa A, Nakahata T, Saito MK*. Induction of human pluripotent stem cell-derived natural killer cells for immunotherapy under chemically defined conditions. Biochem Biophys Res Commun. 2019 Apr 2. pii: S0006-291X(19)30474-7. doi: 10.1016/j.bbrc.2019.03.085. 　解説

• Suga M, Kondo T, Imamura K, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Enami T, Furujo M, Saijo K, Nakamura Y, Osawa M, Saito MK, Yamanaka S, Inoue H. Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I. Stem Cell Res. 2019 Apr;36:101406. doi: 10.1016/j.scr.2019.101406. Epub 2019 Feb 12.

• Ichisima J, Suzuki NM, Samata B, Awaya T, Takahashi J, Hagiwara M, Nakahata T, Saito MK*. Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model. J Hum Genet. 2019 May;64(5):445-458. doi: 10.1038/s10038-019-0574-8. Epub 2019 Mar 8. 　解説

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​2018

• Boisson B, Honda Y, Ajiro M, Bustamante J, Bendavid M, Gennery AR, Kawasaki Y, Ichishima J, Osawa M, Nihira H, Shiba T, Tanaka T, Chrabieh M, Bigio B, Hur H, Itan Y, Liang Y, Okada S, Izawa K, Nishikomori R, Ohara O, Heike T, Abel L, Puel A, Saito MK (co-last author), Casanova JL, Hagiwara M, Yasumi T. Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency. J Clin Invest. 2018 Nov 13. pii: 124011. doi: 10.1172/JCI124011.

• Kirino K, Nakahata T, Taguchi T, Saito MK*. Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition. Sci Rep. 2018 Aug 27;8(1):12865. doi: 10.1038/s41598-018-31256-1.

• Ono H, Ohta R, Kawasaki Y, Niwa A, Takada H, Nakahata T, Ohga S, Saito MK*. Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells. Inflamm Res. 2018 Oct;67(10):879-889. doi: 10.1007/s00011-018-1178-z. Epub 2018 Aug 22.

• Honda-Ozaki F, Terashima M, Niwa A, Saiki N, Kawasaki Y, Ito H, Hotta A, Nagahashi A, Igura K, Asaka I, Li HL, Yanagimachi M, Furukawa F, Kanazawa N, Nakahata T, Saito MK*. Pluripotent stem cell model of Nakajo-Nishimura syndrome untangles proinflammatory pathways mediated by oxidative stress. Stem Cell Reports. 2018 Jun 5;10(6):1835-1850. doi: 10.1016/j.stemcr.2018.04.004. Epub 2018 May 3. 解説

• Oshima K, Saiki N, Tanaka M, Imamura H, Niwa A, Tanimura A, Nagahashi A, Hirayama A, Okita K, Hotta A, Kitayama S, Osawa M, Kaneko S, Watanabe A, Asaka I, Fujibuchi W, Imai K, Yabe H, Kamachi Y, Hara J, Kojima S, Tomita M, Soga T, Noma T, Nonoyama S, Nakahata T, Saito MK*. Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors. Biochem Biophys Res Commun. 2018 Feb 17. pii: S0006-291X(18)30370-X. doi: 10.1016/j.bbrc.2018.02.139. 解説

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2017

• Hitomi H, Kasahara T, Katagiri N, Hoshina A, Mae SI, Kotaka M, Toyohara T, Rahman A, Nakano D, Niwa A, Saito MK, Nakahata T, Nishiyama A, Osafune K. Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice. Sci Transl Med. 2017 Sep 27;9(409). pii: eaaj2300. doi:10.1126/scitranslmed.aaj2300.

• Iki T, Tanaka M, Kitajiri S, Kita T, Kawasaki Y, Mizukoshi A, Fujibuchi W,  Nakagawa T, Nakahata T, Ito J, Omori K, Saito MK*. Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres. PLoS ONE. 2017 12(6): e0179901

• Takada S, Kambe N, Kawasaki Y, Niwa A, Honda-Ozaki F, Kobayashi K, Osawa M, Nagahashi A, Semi K, Hotta A, Asaka I, Yamada Y, Nishikomri R, Heike T, Matsue H, Nakahata T, Saito MK*. Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages. J Allergy Clin Immunol. 2017 Jun 3. pii: S0091-6749(17)30685-1. doi: 10.1016/j.jaci.2017.04.013. 解説

• Kato I, Nishinaka Y, Nakamura M, Akarca AU, Niwa A, Ozawa H, Yoshida K, Mori M, Wang D, Morita M, Ueno H, Shiozawa Y, Shiraishi Y, Miyano M, Gupta R, Umeda K, Watanabe K, Koh K, Adachi S, Heike T, Saito MK, Sanada M, Ogawa S, Marafioti T, Watanabe A, Nakahata T, Enver T. Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGF. Blood 2017 Apr 19. pii: blood-2016-06-721712. doi: 10.1182/blood-2016-06-721712. [Epub ahead of print]

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2016​

• Ohta R, Niwa A, Taniguchi Y, Suzuki N, Toga J, Yagi E, Saiki N, Nishinaka-Arai Y, Okada C, Watanabe A, Nakahata T, Sekiguchi K, Saito MK*. Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells. Scientific Reports, 2016 Nov 2;6:35680. doi: 10.1038/srep35680.解説

• Kawasaki Y, Oda H, Ito J, Niwa A, Tanaka T, Hijikata A, Seki R, Nagahashi A, Osawa M, Asaka I, Watanabe A, Nishimata S, Shirai T, Kawashima H, Ohara O, Nakahata T, Nishikomori R, Heike T, Saito MK*. Pluripotent cell-based phenotypic dissection identifies a high-frequency somatic NLRC4 mutation as a cause of autoinflammation. Arthritis and Rheum, 2016 Oct 27. doi: 10.1002/art.39960. [Epub ahead of print] Editorial

• Sugimine Y, Niwa A, Matsubara H, Kobayashi K, Tabata Y, Heike T, Nakahata T, Saito MK*. A portable platform for stepwise hematopoiesis from human pluripotent stem cells within PET-reinforced collagen sponges. Int J Hematol. 2016 Sep 6. [Epub ahead of print] Review

• Yamashita S, Chiyonobu T, Yoshida M, Maeda H, Zuiki M, Kidowaki S, Isoda K, Morimoto M, Kato M, Saitsu H, Matsumoto N, Nakahata T, Saito MK, Hosoi H.　Mislocalization of syntaxin-1 and impaired neurite growth observed in a human iPSC model for STXBP1-related epileptic encephalopathy. Epilepsia. 2016 Apr;57(4):e81-6. doi: 10.1111/epi.13338. Epub 2016 Feb 25.

• Maeda H, Chiyonobu T, Yoshida M, Yamashita S, Zuiki M, Kidowaki S, Isoda K, Yamakawa K, Morimoto M, Nakahata T, Saito MK, Hosoi H. Establishment of isogenic iPSCs from an individual with SCN1A mutation mosaicism as a model for investigating neurocognitive impairment in Dravet syndrome. J Hum Genet. 2016 Feb 4. doi: 10.1038/jhg.2016.5.

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2015

• Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito MK, Toyoda M, Umezawa A, Hara T. GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells. Exp Hematol. 2015 Oct 23. pii: S0301-472X(15)00674-8. doi: 10.1016/j.exphem.2015.09.007. [Epub ahead of print]

• Yoshida M, Kitaoka S, Egawa N, Yamane M, Ikeda R, Tsukita K, Amano N, Watanabe A, Morimoto M, Takahashi J, Hosoi H, Nakahata T, Inoue H, Saito MK*, Modeling the early phenotype at the neuromuscular junction of spinal muscular atrophy using patient-derived iPSCs. Stem Cell Reports. 2015 Apr 14;4(4):561-8 doi: 10.1016/j.stemcr.2015.02.010 解説

• Suzuki NM, Niwa A, Yabe M, Hira A, Okada C, Amano N, Watanabe A, Watanabe K, Heike T, Takata M, Nakahata T, Saito MK*, Pluripotent cell models of Fanconi anemia identify the early pathological defect in human hemoangiogenic progenitors. Stem Cells Transl Med. 2015 Apr;4(4):333-8. doi: 10.5966/sctm.2013-0172. Epub 2015 Mar 11. 解説

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2014

• Fukuta M, Nakai Y, Kirino K, Nakagawa M, Sekiguchi K, Nagata S, Matsumoto Y, Yamamoto T, Umeda K, Heike T, Okumura N, Koizumi N, Sato T, Nakahata T, Saito M, Otsuka T, Kinoshita S, Ueno M, Ikeya M, Toguchida J. Derivation of Mesenchymal Stromal Cells from Pluripotent Stem Cells through a Neural Crest Lineage using Small Molecule Compounds with Defined Media. PLoS One. 2014 Dec 2;9(12):e112291. doi: 10.1371/journal.pone.0112291. eCollection 2014.

• Yokoyama K, Ikeya M, Umeda K, Oda H, Nodomi S, Nasu A, Matsumoto Y, Izawa K, Horigome K, Kusaka T, Tanaka T, Saito MK, Yasumi T, Nishikomori R, Ohara O, Nakayama N, Nakahata T, Heike T, Toguchida J. Enhanced chondrogenesis of iPS cells from neonatal-onset multisystem inflammatory disease occurs via the caspase-1-independent cAMP/PKA/CREB pathway. Arthritis Rheumatol. 2015 Jan;67(1):302-14. doi: 10.1002/art.38912

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2013

• Nakagawa K, Gonzalez-Roca E, Souto A, Kawai T, Umebayashi H, Campistol JM, Cañellas J, Takei S, Kobayashi N, Callejas-Rubio JL, Ortego-Centeno N, Ruiz-Ortiz E, Rius F, Anton J, Iglesias E, Jimenez-Treviño S, Vargas C, Fernandez-Martin J, Calvo I, Hernández-Rodríguez J, Mendez M, Dordal MT, Basagaña M, Bujan S, Yashiro M, Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike T, Yagüe J, Nishikomori R, Aróstegui JI. Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes. Ann Rheum Dis. 2013 Dec 10. [Epub ahead of print]

• Morishima T, Watanabe KI, Niwa A, Hirai H, Saida S, Tanaka T, Kato I, Umeda K, Hiramatsu H, Saito MK, Matsubara K, Adachi S, Kobayashi M, Nakahata T, Heike T. Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. Haematologica. 2013 Aug 23. [Epub ahead of print] 2014 Jan;99(1):19-27.

• Yanagimachi MD, Niwa A, Tanaka T, Ozaki F, Nishimoto S, Murata Y, Yasumi T, Ito J, Tomida S, Oshima K, Asaka I, Goto H, Heike T, Nakahata T, Saito MK*. Robust and highly-efficient differentiation of functional monocytic cells from human pluripotent stem cells under serum- and feeder cell- free conditions. PLoS One. 2013;8(4):e59243

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2012​

• Tanaka T, Takahashi K, Yamane M, Tomida S, Nakamura S, Oshima K, Niwa A, Nishikomori R, Kambe N, Hara H, Mitsuyama M, Morone N, Heuser JE, Yamamoto T, Watanabe A, Sato-Otsubo A, Ogawa S, Asaka I, Heike T, Yamanaka S, Nakahata T, Saito MK*. Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery. Blood. 2012 Aug 9;120(6):1299-308. Epub 2012 Jun 21. 解説

• Kawai T, Nishikomori R, Izawa K, Murata Y, Tanaka N, Sakai H, Saito M, Yasumi T, Takaoka Y, Nakahata T, Mizukami T, Nunoi H, Kiyohara Y, Yoden A, Mutara T, Sasaki S, Ito E, Akutagawa H, Kawai T, Imai C, Okada S, Kobayashi M, Heike T. Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia with immunodeficiency. Blood. 2012 Jun 7;119(23):5458-66. Epub 2012 Apr 19.

• Kawai T, Saito M, Nishikomori R, Yasumi T, Izawa Km Murakami T, Okamoto S, Mori Y, Nakagawa N, Imai K, Nonoyama S, Wada T, Ohmori K, Nakahata T, Heike T. Multiple reversions of an IL2RG mutation restore T cel function in an X -linked severe combined immunodeficiency patient. J Clin Immunol. 2012 Aug;32(4):690-7. Epub 2012 Mar 30.

• Izawa K, Hijikata A, Tanaka N, Kawai T, Saito MK, Goldbach-Mansky R, Aksentijevich I, Yasumi T, Nakahata T, Heike T, Nishikomori R, Ohara O. Detection of Base Substitution-Type Somatic Mosaicism of the NLRP3 Gene with >99.9% Statistical Confidence by Massively Parallel Sequencing. DNA Res. 2012 Apr;19(2):143-52. Epub 2012 Jan 24.

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2011

• Kato I, Niwa A, Heike T, Fujino H, Saito MK, Umeda K, Hiramatsu H, Ito M, Morita M, Nishinaka Y, Adachi S, Ishikawa F, Nakahata T. Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis. PLoS One. 2011;6(11):e27042. Epub 2011 Nov 1.

• Niwa A, Heike T, Umeda K, Oshima K, Kato I, Sakai H, Suemori H, Nakahata T, Saito MK*. A Novel Serum-Free Monolayer Culture for Orderly Hematopoietic Differentiation of Human Pluripotent Cells via Mesodermal Progenitors. PLoS One. 2011;6(7):e22261. Epub 2011 Jul 27.

• Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Ohara O, Nishikomori R, Morimoto T, Kambe N, Goldbach-Mansky R, Aksentijevich I, de Saint Basile G, Neven B, van Gijn M, Frenkel J, Arostegui JI, Yagüe J, Merino R, Ibañez M, Pontillo A, Takada H, Imagawa T, Kawai T, Yasumi T, Nakahata T, Heike T. High incidence of NLRP3 somatic mosaicism in chronic infantile neurological cutaneous and articular syndrome patients: The results of an international multicenter collaborative study. Arthritis Rheumatol. 2011 Jun 23. doi: 10.1002/art.30512. [Epub ahead of print]

• Murata Y, Yasumi T, Shirakawa R, Izawa K, Sakai H, Abe J, Tanaka N, Kawai T, Oshima K, Saito M, Nishikomori R, Ohara O, Ishii E, Nakahata T, Horiuchi H, Heike T. Rapid diagnosis of FHL3 by flow cytometric detection of intraplatelet Munc13-4 protein. Blood. 2011 Aug 4;118(5):1225-30. Epub 2011 Jun 8.

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2010

• Kambe N, Satoh T, Tanizaki H, Fujisawa A, Saito MK, Nishikomori R. Enhanced　NF-κB activation with an inflammasome activator correlates with activity of　autoinflammatory disease associated with NLRP3 mutations outside of exon 3:　comment on the article by Jéru et al. Arthritis Rheumatol. 2010 Oct;62(10):3123-4;

• Kambe N, Nakamura Y, Saito M, Nishikomori R. The inflammasome, an innate　immunity guardian, participates in skin urticarial reactions and contact　hypersensitivity. Allergol Int. 2010 Jun;59(2):105-13. Epub 2010 Feb 25.

• Kawabata H, Murakami M, Nishikomori R, Saito M, Takaoka Y, Nanao K, Maezawa M.　A Japanese case of familial Mediterranean fever with a MEFV gene mutation. Hokkaido Igaku Zasshi. 2009 Nov;84(6):419-22

• Sakai H, Ito S, Nishikomori R, Takaoka Y, Kawai T, Saito M, Okafuji I, Yasumi T, Heike T, Nakahata T. A case of early-onset sarcoidosis with a six-base　deletion in the NOD2 gene. Rheumatology (Oxford). 2010 Jan;49(1):194-6.

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2009

• Niwa A, Umeda K, Chang H, Saito M, Okita K, Takahashi K, Nakagawa M, Yamanaka S, Nakahata T, Heike T. Orderly hematopoietic development of induced pluripotent stem cells via Flk-1(+) hemoangiogenic progenitors. J Cell Physiol. 2009Nov;221(2):367-77.

• Nakamura Y, Kambe N, Saito M, Nishikomori R, Kim YG, Murakami M, Núñez G,　Matsue H. Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria. J Exp Med. 2009 May11;206(5):1037-46. Epub 2009 Apr 13.

• Okafuji I, Nishikomori R, Kanazawa N, Kambe N, Fujisawa A, Yamazaki S, Saito M, Yoshioka T, Kawai T, Sakai H, Tanizaki H, Heike T, Miyachi Y, Nakahata T. Role　of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset　sarcoidosis. Arthritis Rheum. 2009 Jan;60(1):242-50.

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